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. 2018 Aug 7;24(6):1407–1414. doi: 10.1016/j.celrep.2018.07.023

Figure 4.

Figure 4

Brain-Derived Fgf21 Is Induced in Mouse Models of Neurodegeneration

Data from P301L tau mutant mice (A–D) and RML prion inoculation disease model (E–H).

(A) Western blot of hippocampi of 9-month-old P301L mutant mice and age-matched controls.

(B and C) Quantification of Bip (B) and Atf4 (C) band intensities, normalized to their respective loading control.

(D) Hippocampal Fgf21 mRNA expression of 9-month-old P301L mutant mice and age-matched controls, determined by qRT-PCR. Data represent average + SEM of at least 4 animals.

(E) Western blot of hippocampi of mice intracerebrally inoculated with RML prions at 10 weeks postinoculation (wpi).

(F and G) Quantification of Bip (F) and Atf4 (G) band intensities normalized to their respective loading control.

(H) Fgf21 transcript levels in hippocampi of normal brain homogenate (NBH) or RML prion-inoculated mice at 6, 8, and 10 wpi. Data represent average + SEM of at least 8 animals.