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. 2018 Jul 3;596(16):3585–3602. doi: 10.1113/JP275988

Figure 10. Effects of HCTZ on Na+ and K+ excretion in animals on control and low‐Na diets.

Figure 10

A, dose–response relationships for changes in U Na V and U K V in response to a single injection of HCTZ in rats on standard laboratory chow. B and C, effects of HCTZ (15 mg kg–1) on U Na V (B) and U K V (C) in animals on control diet and on a low‐Na diet for 1, 3 or 7 days. Data represent the mean ± SEM for four to 12 animals. *Statistical difference for the HCTZ‐induced changes in excretion (difference) of the indicated low‐Na group relative to controls [P = 0.005 (3 days), P = 0.0003 (7 days)].