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. 2018 Jul 3;596(16):3585–3602. doi: 10.1113/JP275988

Figure 11. Effects of amiloride + HCTZ on Na+ excretion in animals on control and low‐Na diets.

Figure 11

A, time course of U Na V in response to a single injection of amiloride (1 mg kg–1) + HCTZ (15 mg kg–1) in rats on control‐Na diet. Excretion was almost constant for 1 h and declined during the second hour. B, response of animals on control diet and on a low‐Na diet for 1 or 7 days. Data represent the mean ± SEM for eight to 16 animals. *Statistical difference of the 7‐day low‐Na group relative to controls (P = 0.0002).