Figure 8. Role of intracellular Ca²⁺ stores in generating pericyte Ca²⁺ transients in different microvascular segments.

In a PCA, CPA (10 μm) abolished spontaneous Ca²⁺ transients in pericytes and increased the basal Ca²⁺ level (A). In another PCA, caffeine (1 mm) prevented the generation of spontaneous Ca²⁺ transients in pericytes (B). In a different PCA, tetracaine (100 μm) abolished spontaneous Ca²⁺ transients in pericytes (C). In a capillary, CPA (10 μm) abolished spontaneous Ca²⁺ transients in pericytes associated with a rise in the basal Ca²⁺ level (D). In another capillary, caffeine (1 mm) prevented the generation of spontaneous Ca²⁺ transients in pericytes (E). In the same capillary, tetracaine (100 μm) abolished spontaneous Ca²⁺ transients in pericytes (F). In a PCV, CPA (10 μm) prevented the generation of spontaneous Ca²⁺ transients in pericytes associated with a rise in the basal Ca²⁺ level (G). In another PCV, caffeine (1 mm) abolished spontaneous Ca²⁺ transients in pericytes (H). In a different PCV, tetracaine blocked spontaneous Ca²⁺ transients in pericytes (I). [Color figure can be viewed at http://wileyonlinelibrary.com]