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. 2018 Jul 23;596(16):3603–3616. doi: 10.1113/JP275952

Figure 4. Simvastatin attenuated TGF‐β1‐induced EMT and Erk1/2 phosphorylation in renal tubular cells.

Figure 4

Representative western blot images (A) and summarized data (B) showing the inhibitory effect of simvastatin on TGF‐β1‐induced decrease in epithelial marker E‐cad, and increases in mesenchymal markers α‐SMA and FSP‐1. C, representative western blot images (upper panel) and summarized data (lower panel) showing the inhibitory effect of simvastatin on TGF‐β1‐induced Erk1/2 phosphorylation. E‐Cad, E‐cadherin; α‐SMA, α‐smooth muscle actin; FSP‐1, fibroblast‐specific protein‐1. Results are the means ± SEM of measurements from five separate preparations. * P < 0.05, † P < 0.05 and # P < 0.05 vs. other groups for E‐cadherin, α‐SMA and FSP‐1, respectively in B; * P < 0.05 vs. other groups in C.