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. 2018 Jul 19;596(16):3505–3529. doi: 10.1113/JP275973

Figure 14. Bilateral superior cervical ganglionectomy in SHR attenuates sympathetic fibre innervation of vertebrobasilar arteries but is without effect on their remodelling.

Figure 14

A, representative images of vertebrobasilar arteries showing immunofluorescence staining α‐DBH‐AF594 and α‐VAChT‐AF488 after SCGx or sham operation in SHR and corresponding bright field (BF) images. The arrowheads indicate exemplar sympathetic fibres stained with DBH antibody. B, the reduction in DBH staining is clearly evident after ganglionectomy. Percentage change in sympathetic (DBH positive) and parasympathetic (VAChT positive) fibre densities in SCGx compared to sham animals according to area. Significant differences to normalised sham values are indicated on the graph: * P < 0.05, *** P < 0.001. C, coronal images of the basilar and vertebral arteries in SCGx and sham operated SHR. There is no evidence of remodelling in the 14 days since ganglionectomy in SCGx in comparison to sham operated rats. [Color figure can be viewed at http://wileyonlinelibrary.com]