Table 1.
Vigilance states, NREM and REM sleep episodes in Gria1−/− and wild-type mice (Gria1 + / + )
| Gria1 + / + | Gria1 -/- | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| BASELINE | WAKING | NREMS | REMS | NREM episodes | REM episodes | WAKING | NREMS | REMS | NREM episodes | REM episodes |
| Light | 31.9 (2.0) | 54.5 (2.3) | 10.4 (0.6) | 79.3 (4.7) | 84.1 (7.2) | 41.8 (4.4) a | 47.8 (3.7) | 8.1 (0.6)° | 60.3 (4.2) a | 56.0 (6.4) a |
| Dark | 77.1 (2.9) | 19.7 (2.5) | 2.2 (0.4) | 22.5 (4.4) | 16.4 (2.7) | 72.0 (4.0) | 23.5 (3.3) | 3.2 (0.6) | 26.5 (4.2) | 19.8 (4.0) |
| 24-h | 54.5 (1.6) | 37.2 (1.9) | 6.3 (0.3) | 101.5 (7.3) | 100.5 (8.2) | 56.8 (3.1) | 35.7 (2.5) | 5.6 (0.4) | 86.8 (6.9) ° | 75.8 (7.8) ° |
| SLEEP DEPRIVATION | 98.8 (0.6) | 1.2 (0.5) | 0.0 | 1.0 (0.6) | 0.0 | 99.8 (0.1)a | 0.1 (0.1)a | 0.0 | 0.0 | 0.0 |
| RECOVERY Light | 27.8 (4.5) | 58.4 (4.0) | 10.9 (0.6) | 33.8 (1.6) | 39.3 (2.0) | 25.3 (2.5) | 61.5 (2.1) | 10.6 (0.4) | 32.0 (2.0) | 31.7 (2.3) ° |
| Dark | 73.8 (2.3) | 21.7 (1.9) | 3.3 (0.4) | 24.1 (4.1) | 21.4 (4.2) | 62.0 (4.7) a | 31.1 (3.9) ° | 5.2 (0.7)a | 41.2 (4.7) a | 34.8 (4.6) |
Mean values (SEM in parenthesis, Gria1+/+: n=8, Gria1-/-: n=6) of waking, NREM sleep (NREMS) and REM sleep (REMS) expressed as percentage of recording time, and the total number of NREMS and REMS episodes, shown for the 12-h light and dark period of baseline day, 6-h sleep deprivation (SD) and 18-h recovery. SD began at light onset. Differences between genotypes: ° p<0.1, a p<0.05, Wilcoxon rank sum test