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. 2018 Aug 14;8:155. doi: 10.1038/s41398-018-0208-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Representative traces from individual experiments before and 1 h after HFS b LTP produced in the ZL006 treated cells following HFS was significantly depressed compared with vehicle and ZL007 conditions (Treatment: F_{2, 1243} = 434.0, P < 0.0001). Multiple comparisons post hoc analysis revealed that EPSP responses in cells treated with ZL006 were different from cells treated with vehicle or ZL007 at all time point t > 16 minutes (P < 0.05) (n = 10, 6 and 6 for vehicle, ZL007 and ZL006, respectively). c Membrane resistance was not different when compared between groups or over time (n = 8, 6, and 5 for vehicle, ZL007 and ZL006, respectively). Arrow indicates initiation of high frequency stimulation (HFS)