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. 2018 Aug 14;8:12148. doi: 10.1038/s41598-018-29809-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Examples of the time course of PEsen ESM metabolites following the induction of IrrDSBsen. The figure shows examples of four different patterns of ESM kinetics. Late accumulation (cysteine glutathione disulphide), early accumulation followed by late decline (3-(4-hydroxyphenyl)lactate), early accumulation followed by stabilisation (pyridoxate) and late depletion (glycylphenylalanne). The figure shows the time course of each detectable ESM PEsen metabolite after the induction of IrrDSBsen over a 20 day period in two oral fibroblast lines NHOF-1 (blue) and NHOF-5 (red). The symbols for the box and whisker plots are as follows; + = mean value, the horizontal lines within the boxes = median value, O = extreme points, the limits of the boxes = the upper and lower quartiles and the error bars indicate the maxima and minima of distribution.