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. 2018 Aug 14;8:12143. doi: 10.1038/s41598-018-30547-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Integrated analysis of rifamycin ADP-ribosyltransferase (Arr). (a) The sequence conservation of rifamycin ADP-ribosyltransferase (Arr). The residues that are conserved more than 78% of the sequences are highlighted based on the clustalw color scheme. The genes selected for experimental validation are shown as wd1-wd4. (b) Proposed key residues and their molecular interactions in the rifampin-binding sites of Arr-ms structure (PDB 2HW2). In Arr-ms, the variable X residue in M[R|K][D|E]XL motif is Gly129, and its position is highlighted with a red arrow. Water molecules are depicted with spheres.