Figure S2.

Genomic Organization and Structure of NOTCH2NL Family Gene Members, Related to Figure 3

(A) Genomic organization of 1p12 and 1q21.1-2, where NOTCH2-family genes are located. Genes located in these regions are depicted as arrows (HS genes in magenta and other single copy genes in gray) according to the human reference genome (GRCh38/hg38).

(B) Gene structure of NOTCH2-family members. Protein coding region is indicated by arrows and different colors indicate the protein domains. Amino acid substitutions among the members are indicated above the arrows.

(C) Alignment of amino acid sequences of 5 NOTCH2-family gene products. Protein motifs indicated above the alignment is derived from the prediction for human NOTCH2 (Uniprot; Q04721). The variable amino acid residues, except for those in the C terminus, are indicated by asterisks.