Table 1.
Pathways and gene list that were reversed with riluzole treatment
| Pathways | Genes that are upregulated with 5XFAD and downregulated with riluzole | Pathways | Genes that are downregulated with 5XFAD and upregulated with riluzole |
|---|---|---|---|
| Immunity | BST2, CLEC7A, CYBB, H2-Q2, IFIT3, IRF7, LBP, LY9, MX1, MX2, Oas1a, OAS2, OAS3, Oasl2, RSAD2, TNFRSF17, TRIM14 | Glycoprotein | Col6a4, HTR1B, IGFBPL1, IGSF9B, pcsk1, PI15, SLC9A3 |
| Glycoprotein | 1500015O10Rik, ABCA4, ACE, AQP1, BMP4, BMP6, BST2, Ccl9, CD5, CDH3, CLDN2, CLEC1A, CLEC7A, CLEC9A, COL17A1, COL4A3, COL4A4, COL8A1, COL8A2, COL9A3, CXCL5, CYBB, Defb11, ENPP2, F5, FAP, folr1, FOLR2, GLB1L2, H2-Q2, HCST, Ifi27l2a, IGFBP2, IGFBP5, IL15, ITPRIPL1, KCNE2, KL, KRT18, KRT8, LARGE2, LBP, LGALS3BP, LY9, MAMDC2, MFRP, Mfsd4b1, MIA, NOX1, oacyl, OAS2, OCA2, PRLR, SCTR, SEMA3B, SFRP1, SLAMF8, SLC2A12, SLC39A4, Slco1a5, SOSTDC1, SULF1, tmc8, TMPRSS11A, TNFRSF17, TNFSF8, TNS4, TTR, Vmn2r84, WFDC2, WFIKKN2 | Signal | Col6a4, IGFBPL1, IGSF9B, pcsk1, PI15 |
| Cell junction | IGSF9B | ||
| Collagen | COL17A1, COL4A3, COL4A4, COL8A1, COL8A2, COL9A3, MFRP, TNFSF8 | ||
| Netrin domain | SFRP1, WFIKKN2 | ||
| GTP binding | 9330111J21Rik1, GBP3, Gm12185, Gm4951, Gm5431, GNA15, MX1, MX2, RAB20, RHOD | ||
| Scanvenger receptor activity | CD5, ENPP2, LGALS3BP |