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. 2018 Aug 14;8:12083. doi: 10.1038/s41598-018-29441-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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REST-DRD2 pathway regulates spontaneous locomotion in D-hREST mice. (a) D-hREST male mice showed significantly decreased spontaneous locomoter activity, as determined by open field assay performed for 15 min. Open-field data were calculated in terms of immobile score, speed, and total distance. P values are shown in the figure. N for D-hREST mice = 5; N for LSL-hREST mice = 5. (b) D-hREST female mice also showed significantly decreased spontaneous locomoter activity, as determined by open field assay performed for 15 min. P values are shown in the figure. N for D-hREST mice = 3; N for LSL-hREST mice = 7. (c,d) Both D-hREST male (c) and female (d) mice showed significantly decreased spontaneous locomoter activity when assayed for 5 min. The experiments were performed using the open field assay and the data were calculated in terms of immobile score, speed, and total distance. P values are shown in the figure. N for D-hREST male mice = 5; N for LSL-hREST male mice = 5. N for D-hREST female mice = 3; N for LSL-hREST female mice = 7. (e) Motor coordination test using the rotarod assay in male mice. N for each group = 8. P values are shown in the figure.