Table 2.
The association between different prognostic factors and OS at 6 and 12 months in CBF-AML.
| Prognostic factors | Pediatrics N = 34 |
Adults N = 34* |
||||||
|---|---|---|---|---|---|---|---|---|
| N | 6 months | Median | N | 6 months | 12 months | Median | ||
| t(8;21) (q22.q22) | ||||||||
| Negative | 12 | 39.3 | 0.8 | 13 | 37.0 | 37.0 | 1.6 | |
| Positive | 22 | 31.9 | 2.5 | 21 | 75.0 | 62.9 | - | |
| p value | 0.844 | 0.17 | ||||||
| FAB | ||||||||
| M1 = M2 | 21 | 28.7 | 2.5 | 21 | 76.5 | 62.6 | − | |
| M4 + M4 | 13 | 49.2 | 0.8 | 13 | 43.3 | 43.3 | 5 | |
| p value | 0.77 | 0.09 | ||||||
| Inv 16 | ||||||||
| Negative | 22 | 31.9 | 2.5 | 21 | 75.0 | 62.9 | – | |
| Positive | 12 | 39.3 | 0.8 | 13 | 37.0 | 37.0 | ||
| p value | 0.77 | 0.09 | ||||||
| Platelets | ||||||||
| ≤ 20 × 109 /L | 10 | 54.0 | 6 | 12 | 81.8 | 81.8 | − | |
| > 20 × 109/L | 24 | 30.0 | 2.3 | 22 | 51.8 | 39.3 | 8.7 | |
| p value | 0.7 | 0.047 | ||||||
| TLC | ||||||||
| < 20 × 109 /L | 12 | 45.0 | 3 | 21 | 68.4 | 61.9 | − | |
| ≥ 20 × 109/L | 22 | 32.0 | 2.3 | 13 | 54.9 | 44.0 | 8.7 | |
| p value | 0.415 | 0.211 | ||||||
| HGB | ||||||||
| ≤ 8 g/dl | 24 | 41.2 | 3 | 19 | 70.1 | 55.2 | - | |
| > 8 g/dl | 10 | 25.9 | 2.3 | 15 | 55.3 | 55.3 | - | |
| p value | 0.235 | 0.758 | ||||||
| Hepatomegaly | ||||||||
| Negative | 24 | 24.1 | 1.9 | 23 | 69.1 | 69.8 | – | |
| Positive | 10 | 66.7 | 6.0 | 11 | 51.1 | 40.9 | ||
| p value | 0.10 | 0.262 | ||||||
| Splenomegaly | ||||||||
| Negative | 28 | 29.1 | 2.3 | 25 | 69.3 | 53.0 | - | |
| Positive | 6 | 60 | - | 9 | 59.3 | 59.3 | - | |
| p value | 0.183 | 0.832 | ||||||
Data are presented as n (%). FAB: French-American-British classification,FLT3 ITD: Fms-like Tyrosine Kinase Internal Tandem Duplication, FLT3 TKD: Fms-like Tyrosine Kinase Tyrosine Kinase Domain, HGB: Hemoglobin, PLT: Platelets count, TLC: Total Leukocyte Count, PB Blast: Peripheral Blood Blast, BM Bone marrow blasts. *Data are presented for 34 adult patients only.