Figure 2.

Functional Imaging of Orthotopic Glioblastoma. Panels A & E show the location of the tumor in a representative animal 15 and 42 days post inoculation respectively. Panels B & F show the sO₂ fraction map after reconstruction using back-projection and unmixing using linear regression of the corresponding animals. Panels C and G denote the sO₂ fraction map after combined non-negative constrained reconstruction and unmixing in the corresponding animals. Panels D and H show the sO₂ values in the tumor and the contralateral side of the brain in animals 15 (n = 5) and 42 (n = 3) day post inoculation. sO₂ values between the tumor and contralateral side were found to be statistically significantly different using paired t-test. * - P < 0.05; ** - P < 0.01.