Figure 3.

Histological validation of sO₂ values observed on MSOT. Panels A & D show mitotic cells (black arrow) in the histological sections of H&E stained tumors 15 and 42 days post inoculation. Panels B & E show corresponding tissue sections of tumors stained for CD34, a marker for neovasculature and panels C and F, areas stained for CAIX (a marker for hypoxia). Panels G and H shows the quantification of CD34 and CAIX stains respectively in tumors 15 and 42 days post inoculation. Red arrow indicates hypoxic cells.