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Modes of DSB repair in cell cycle phases. DSB repair by HR and alt-NHEJ requires CtIP and MRN activity and takes place in S and G2 phases of the cell cycle. DSB repair by c-NHEJ occurs predominately, but not exclusively, in the G1 phase. p53 functions to restrict DSB resection for HR and alt-NHEJ, while possibly promoting accurate c-NHEJ.
