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. 2018 Aug 8;9:1850. doi: 10.3389/fimmu.2018.01850

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Copyright © 2018 Higashisaka, Nakashima, Iwahara, Aoki, Nakayama, Yanagihara, Lin, Nagano, Tsunoda, Saito, Yoshioka and Tsutsumi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of neutrophil depletion on pregnancy complications in silica nanoparticles with a diameter of 70 nm (nSP70)-treated mice. Pregnant BALB/c mice were treated intraperitoneally with anti-Ly-6G or isotype-matched control antibodies (150 μg/mouse) on gestational day (GD) 15; 24 h later, mice received either nSP70 or saline by intravenous injection. The uteri were excised on GD 17. (A) Representative placentae and fetuses. (B) Placental weight and (C) fetal weight were assessed. Data are presented as means ± SEM; n = 9 or 10; **P < 0.01.