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. 2018 Aug 8;12:255. doi: 10.3389/fncel.2018.00255

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Copyright © 2018 Tang, Lin, Pan and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The behavioral effects of FGFR inhibitor (SU5402). (A) The timeline of Experiment 2. Two groups respectively received 2 μg or 5 μg doses of central SU5402 infusions for five consecutive days. Dimethyl sulfoxide (DMSO) was used as Vehicle in control group. (B) Saccharin preference test. A 5 μg dose of SU5402 infusions induced significant decreased ratio of saccharin intake. (C,D) OFT. A 5 μg dose of SU5402 infusions decreased the distance traveled and rearing times. One-way ANOVA with Dunnett’s multiple comparisons test, n = 6 per group. Data are presented as the means ± SEM. *p < 0.05, **p < 0.01. i.c.v., intracerebroventricular; SPT, Saccharin preference test; OFT, Open field test.