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. 2018 Aug 8;12:255. doi: 10.3389/fncel.2018.00255

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Copyright © 2018 Tang, Lin, Pan and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of FGFR inhibitor (SU5402) on the microglia activation in hippocampus. (A1–A3) Representative photographs of Iba1 expression in hippocampus. Compared with the DMSO group, there were increased expression of microglia identification marker Iba1 and more Iba1 positive cells in CA1 and DG with the swollen soma and retracted processes in 5 μg dose of SU5402 group. (B) The percentage of Iba1 positive area was increased by 5 μg dose of SU5402. (C) The density of Iba1 positive cells was increased by 5 μg dose of SU5402. (D) The area of microglia soma was increased by 5 μg dose of SU5402. (E) The length of microglial processes was decreased by 5 μg dose of SU5402. One-way ANOVA with Dunnett’s multiple comparisons test, n = 4 per group. Data are presented as the means ± SEM. **p < 0.01, ***p < 0.001. DMSO, dimethyl sulfoxide; DG, dentate gyrus.