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. 2018 Aug 8;12:226. doi: 10.3389/fncel.2018.00226

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Copyright © 2018 Varidaki, Hong and Coffey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical development of microtubule stabilizing agents for Alzheimer's and Parkinson's disease, schizophrenia and cancer. Microtubule stabilizing agent grouping is according to pre-clinical, or clinical phases. Drugs developed for cancer are in gray; those for Alzheimer's and Parkinson's diseases are coded orange and pink respectively, and those under development for treatment of schizophrenia are in dark purple. We denote blood brain barrier (BBB) penetrance with upright triangles and non-penetrant drugs with an upside down triangle.