Table 1.
Tissue contents of NA and MHPG (represents in ng/g of tissue) in the frontal cortex and hippocampus of mice brain were measured by HPLC, and the ratios of MHPG/NA were analyzed after DSP-4, pCPA, and MPTP administration respectively.
| Treatments | Frontal cortex | Hippocampus | ||||
|---|---|---|---|---|---|---|
| NA | MHPG | MHPG/NA | NA | MHPG | MHPG/NA | |
| Saline (n = 12) | 224.3 ± 16.1 | 57.3 ± 3.5 | 0.25 ± 0.03 | 303.7 ± 22.1 | 104.6 ± 12.6 | 0.34 ± 0.07 |
| DSP-4 (n = 10) | 88.5 ± 7.6*** | 36.8 ± 4.9* | 0.43 ± 0.09* | 125.4 ± 19.4*** | 69.5 ± 10.6* | 0.55 ± 0.09* |
| pCPA (n = 12) | 212.7 ± 18.4 | 46.9 ± 2.7 | 0.21 ± 0.04 | 284.9 ± 26.6 | 106.7 ± 14.2 | 0.37 ± 0.04 |
| MPTP (n = 9) | 228.5 ± 20.6 | 45.1 ± 4.5 | 0.19 ± 0.05 | 315.8 ± 20.9 | 89.2 ± 9.5 | 0.28 ± 0.04 |
| DSP-4/pCPA (n = 11) | 79.5 ± 9.4*** | 39.6 ± 3.8* | 0.51 ± 0.11* | 127.2 ± 15.5*** | 63.2 ± 5.3* | 0.49 ± 0.07* |
| DSP-4/MPTP (n = 9) | 91.7 ± 8.4*** | 45.4 ± 3.1 | 0.48 ± 0.05* | 131.5 ± 16.9*** | 75.6 ± 8.5* | 0.57 ± 0.08* |
| pCPA/MPTP (n = 10) | 201.5 ± 23.4 | 53.6 ± 6.7 | 0.26 ± 0.07 | 296.4 ± 36.7 | 92.7 ± 7.3 | 0.31 ± 0.03 |
| DSP-4/pCPA/MPTP (n = 11) | 66.7 ± 10.4*** | 32.7 ± 5.1** | 0.49 ± 0.06* | 116.3 ± 20.1*** | 78.2 ± 7.9* | 0.67 ± 0.12** |
All values are expressed as mean ± S.E.M.
*
p < 0.05,
**
p < 0.01,
***
p < 0.001 in comparison with the saline group.