Table 3.

Tissue contents of DA, DOPAC, and HVA (represents in ng/g of tissue) in the frontal cortex and striatum of mice brain were measured by HPLC, and the ratios of (DOPAC + HVA)/DA were analyzed after DSP-4, pCPA, and MPTP administration respectively.

Treatments	Frontal cortex				Striatum
	DA	DOPAC	HVA	(DOPAC+HVA)/DA	DA	DOPAC	HVA	(DOPAC+HVA)/DA
Saline (n = 12)	521.7 ± 45.8	32.8 ± 2.6	48.9 ± 3.1	0.15 ± 0.06	7,020 ± 551.4	617.7 ± 56.8	997.8 ± 78.2	0.23 ± 0.04
DSP-4 (n = 10)	506.4 ± 27.9	30.3 ± 4.3	43.1 ± 5.3	0.14 ± 0.05	6,742 ± 600.7	553.8 ± 58.4	889.9 ± 96.3	0.21 ± 0.08
pCPA (n = 12)	531.5 ± 28.4	34.4 ± 2.9	56.5 ± 6.1	0.17 ± 0.05	6,574 ± 391.6	698.2 ± 67.3	941.4 ± 88.5	0.25 ± 0.08
MPTP (n = 9)	496.9 ± 44.1	36.8 ± 5.1	69.5 ± 5.6	0.21 ± 0.07	1,494 ± 155.8***	347.9 ± 25.7***	543.5 ± 63.1***	0.59 ± 0.12**
DSP-4/pCPA (n = 11)	507.5 ± 44.6	28.9 ± 3.5	43.6 ± 4.4	0.14 ± 0.06	7,175 ± 532.4	603.7 ± 67.6	897.8 ± 74.4	0.21 ± 0.04
DSP-4/MPTP (n = 9)	473.9 ± 20.5	34.1 ± 3.6	52.1 ± 3.7	0.18 ± 0.06	847.7 ± 71.0***##	189.1 ± 23.1***	235.6 ± 21.3***	0.51 ± 0.11**
pCPA/MPTP (n = 10)	474.8 ± 28.9	31.7 ± 2.9	42.6 ± 3.2	0.15 ± 0.04	977.2 ± 105.6***#	213.3 ± 24.4***	231.2 ± 18.4***	0.45 ± 0.12*
DSP-4/pCPA/MPTP (n = 11)	127.1 ± 15.9***	10.7 ± 1.2***	24.6 ± 2.1**	0.28 ± 0.08**	620.4 ± 81.3***###	165.4 ± 19.9***	193.2 ± 15.7***	0.57 ± 0.14**

All values are expressed as mean ± S.E.M.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001 in comparison with saline group;

^#p < 0.05,

^##p < 0.01,

^###p < 0.001 in comparison with MPTP group.