Table 2.
Median (IQR) TTP by patient and infection characteristics and adjusted* estimates of TTP investigating potential predictive factors in a generalized linear model.
| n (%) | TTP, Median (IQR), h | Multivariable model | ||
|---|---|---|---|---|
| Estimated TTP (95% CI)a | Adjusted p-valueb | |||
| Age groups | p = 1.0 | |||
| <28 days | 196 (38%) | 11.3 (7.57–18.7) | Reference | |
| 28–365 days | 125 (24%) | 11.0 (8.40–15.6) | 0.95 (0.79–1.13) | |
| 1–4 years | 93 (18%) | 12.0 (9.12–16.2) | 1.01 (0.82–1.25) | |
| 5–9 years | 53 (10%) | 11.9 (9.00–16.2) | 0.97 (0.75–1.25) | |
| 10–16 years | 54 (10%) | 12.0 (8.62–16.5) | 0.94 (0.73–1.20) | |
| Sex | p = 0.3 | |||
| Male sex | 311 (60%) | 11.3 (8.12–17.2) | Reference | |
| Female sex | 210 (40%) | 12.0 (8.50–16.8) | 1.07 (0.94–1.22) | |
| Comorbidity | p = 0.1 | |||
| No comorbidity | 230 (44%) | 12.0 (8.93–16.9) | Reference | |
| Comorbidity present | 291 (56%) | 11.0 (7.50–17.1) | 0.85 (0.72–1.01) | |
| Severity of sepsis | p = 0.9 | |||
| Sepsis | 324 (62%) | 11.7 (8.67–16.6) | Reference | |
| Severe sepsis | 100 (19%) | 12.4 (7.56–19.6) | 0.96 (0.80–1.15) | |
| Septic shock | 97 (19%) | 11.3 (7.50–15.1) | 1.00 (0.84–1.19) | |
| Site or type of infection | p = 0.1 | |||
| Central-line associated bloostream | 151 (29%) | 11.9 (7.65–18.1) | Reference | |
| Primary bloodstream | 104 (20%) | 10.1 (7.17–14.4) | 0.94 (0.76–1.17) | |
| Urinary tract | 56 (11%) | 11.0 (8.12–15.4) | 1.27 (0.97–1.65) | |
| Pneumonia | 45 (9%) | 13.2 (10.3–16.2) | 1.28 (0.95–1.74) | |
| Central nervous system | 40 (8%) | 10.0 (8.33–14.7) | 0.94 (0.69–1.28) | |
| Gastrointestinal system | 32 (6%) | 11.8 (7.88–18.2) | 1.32 (0.99–1.76) | |
| Bones and joints | 30 (6%) | 14.1 (11.3–20.1) | 1.04 (0.72–1.49) | |
| Skin and soft tissue | 30 (6%) | 12.5 (9.35–16.7) | 1.06 (0.79–1.42) | |
| Other specific infection typeb | 33 (6%) | 12.0 (9.00–19.5) | 1.20 (0.88–1.62) | |
| Pathogens | p < 0.001 | |||
| Coagulase-negative staphylococci | 84 (16%) | 16.2 (10.4–23.1) | Reference | |
| Staphylococcus aureus | 77 (15%) | 14.0 (9.12–17.1) | 0.74 (0.57–0.95) | |
| Group B streptococci | 47 (9%) | 8.70 (5.95–10.2) | 0.44 (0.33–0.59) | |
| Streptococcus pneumoniae | 46 (9%) | 11.4 (9.05–13.9) | 0.53 (0.37–0.74) | |
| Other Gram-positive bacteriac | 82 (16%) | 13.2 (10.0–19.8) | 0.81 (0.63–1.03) | |
| Escherichia coli | 97 (19%) | 9.20 (6.68–12.0) | 0.56 (0.43–0.71) | |
| Other Gram-negative bacteriad | 88 (17%) | 11.9 (8.54–18.7) | 0.80 (0.62–1.04) | |
*
The adjusted model was adjusted for all variables listed
a
Values and 95% CI are relative to the defined reference group
b
P-value from likelihood ratio test. Endocarditis, toxic shock syndrome, ear, nose, and throat infection, and other non-specified focal infections.
c
Enterococcus spp., group A streptococcus, viridans group streptococci, other Gram positive bacteria.
d
Haemophilus influenzae, Klebsiella spp., Neisseria meningitidis, Pseudomonas aeruginosa, other Gram negative bacteria.