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. 2018 Aug 14;24(30):3384–3397. doi: 10.3748/wjg.v24.i30.3384

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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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KEGG pathway analysis of the cytokines related to the development of ulcerative colitis. A: Eleven of all the major signaling pathways of the up-regulated cytokines in the model group (compared with the normal group) are involved in the interaction between cytokines and their receptors (36.7%); B: Of the major signaling pathways of the down-regulated cytokines in the model group (compared with the normal group), 13 pathways regulate the interaction between cytokines and their receptors (39.4%) (Supplementary Tables 4 and 5).