Table 1.
Diagnostic criteria for non-alcoholic fatty liver disease according to the various guidelines
EASL | NICE | Asia-Pacific | AISF | AASLD | |
Required criteria | Steatosis in > 5% of hepatocytes by either imaging or histology | Excessive fat in the liver | Hepatic steatosis by either imaging or histology | Hepatic steatosis on either imaging or histology | Evidence of hepatic steatosis either by imaging or histology |
No other causes of steatosis | No other causes of steatosis | No other causes of steatosis | No other causes of steatosis | No other causes of steatosis | |
Insulin resistance | No significant alcohol consumption | No significant alcohol consumption | No significant alcohol consumption | No significant alcohol consumption | |
No coexisting chronic liver disease | |||||
Alcohol consumption threshold (men) | 30 g/d | 30 g/d | 2 standard drink/d | 30 g/d | 21 standard drink/wk |
140 g/wk | 294 g/wk | ||||
Alcohol consumption threshold (women) | 20 g/d | 20 g/d | 1 standard drink/d | 20 g/d | 14 standard drink/wk |
70 g/wk | 196 g/wk |
EASL: European Association for the Study of the Liver; NICE: National Institute for Health and Care Excellence; AISF: Italian Association for the study of the Liver; AASLD: American Association for the Study of Liver Diseases; MRI: Magnetic resonance imaging.