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. 2018 Jul 26;37(16):e99429. doi: 10.15252/embj.201899429

Figure EV4. Treatment with Vi polysaccharide reduces disease pathology in EAE animal models.

Figure EV4

  • A
    The average total EAE disease score of Vi polysaccharide‐treated mice shows a significant reduction in disease severity.
  • B, C
    Mice from the EAE experiment depicted (A) and in Fig 3F were sacrificed on day 15 of EAE and the brains were worked up to check for (B) FOXP3 and (C) IL‐17 levels. Vi polysaccharide treatment showed no effect on CD4+IL‐17+ cell numbers in the brain. Vi polysaccharide‐treated mice showed higher FOXP3 expression in CD4+ cells in the brain.
  • D
    Mice undergoing EAE were worked up either at the onset of the disease (score 0.5) or at the peak of the disease (score 3). The expression of surface PHB1 was monitored in CD4+ cells from the CNS.