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. 2018 Jul 5;11(2):514–521. doi: 10.1016/j.stemcr.2018.06.004

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© 2018 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

NSGL Rats Can Be Engrafted with Human Hematopoietic Stem Cells to Develop Multi-lineage hCD45⁺ Human Leukocytes

(A and B) Human B cells and macrophages, but not human T cells, were readily detected within the PBMCs (A) and bone marrow (BM) (B) of NSGL rats 5 weeks after being transfused with CD34⁺ human fetal liver cells. The percentage of the hCD45⁺ cells within the leukocyte population is indicated in the top panel. The percentage of human B cells, T cells, and macrophages within the hCD45⁺ human leukocyte population is indicated in the bottom panel. PBMC and BM of the WT rats were used as negative controls for immunostaining.

(C) Statistical analysis of the percentage of the hCD45⁺ cells within all leukocytes as well as the percentage of B cells and T cells within the gated hCD45⁺ cell population in SG and NSGL rats transplanted with hHSCs. The engraftment rate (the number of rats with human cell engraftment versus the total rats transplanted) is indicated. Mean values ± SD are presented.