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. 2018 Aug 8;9:887. doi: 10.3389/fphar.2018.00887

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Copyright © 2018 Li, Yang, Fang, Zhan, Huang, Gao, Xu, Hashimoto and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of Keap1 and Nrf2 proteins in selected tissues among the sham, anhedonia-susceptible, and anhedonia-resilient groups. (A) Keap1 [F_(2,15) = 9.477_, P = 0.02] and Nrf2 [F_(2,15) = 11.497_, P = 0.013] levels in the mPFC. (B) Keap1 [F_(2,15) = 1.811, P = 0.243] and Nrf2 [F_(2,15) = 0.289, P = 0.759] levels in the NAc. (C) Keap1 [F_(2,15) = 10.833_, P = 0.01] and Nrf2 [F_(2,15) = 9.248_, P = 0.015] levels in the hippocampus. (D) Keap1 [F_(2,15) = 62.237_, P = 0.011] and Nrf2 [F_(2,15) = 31.095_, P < 0.001] levels in the L2-5 spinal cord. (E) Keap1 [F_(2,15) = 6.35_, P = 0.033] and Nrf2 [F_(2,15) = 144.8_, P < 0.001] levels in the muscle. (F) Keap1 [F_(2,15) = 25.886_, P = 0.001] and Nrf2 [F_(2,15) = 22.201_, P = 0.002] levels in the liver. Data are shown as mean ± SEM (n = 6). ^∗P < 0.05, ^∗∗P < 0.01, or ^∗∗∗P < 0.01. Keap1, kelch-like ECH-associated protein 1; mPFC, medial prefrontal cortex; NAc, nucleus accumbens; Nrf2, nuclear factor (erythroid 2-derived)-like 2; N.S., not significant.