Table 4.

Changes in brain endothelial tight and adherens junction proteins after SAH.

Publication	Model	Change with SAH	Intervention
Yan et al.67	Rat/EP	↓ Occludin (WB, IHC) 24 h	Pifithrin-α (p53 inhibition)
Simard et al.78	Rat/EP	Occludin redistribution IHC	Glibenclamide
Sozen et al.71	Mouse/EP	↓ ZO-1 (WB) 24 h	IL-1β converting enzyme inhibition
Hasegawa et al.66	Rat/EP	↓ Occludin (WB) 24 h	Na orthovanadate
Fujii et al.62	Rat/EP	↓ Occludin/ZO-1 (WB) 24 h	Hydroxyfasudil (ROCK inhibition)
Wang et al.75	Rat/BI	↓ Occludin/ZO-1 (WB) 48 h	HIF-1α, MMPs, aquaporin-4
Chen et al.58	Rat/EP	↓ occludin/ZO-1 (WB/IHC) 24 h	c-Jun N-terminal kinase inhibition
Altay et al.69	Mice/EP	↓ Claudin-5/ZO-1/JAM-A/VE-cadherin (WB) 24 h	Isoflurane
Chen et al.59	Rat/EP	↓ Occludin/ZO-1/claudin-5 (WB) 24 h	Melatonin
Fujii et al.63	Rat/EP	↓ ZO-1 (WB) 24 h	Cannabanoid-2 receptor
Li et al.34	Rat/EP	↓ Occludin/ZO-1 ↔claudin-5 (WB, IHC) 0.5 – 168 h	None
Chen et al.60	Rat/EP	↓ Occludin/ZO-1/claudin-5/VE-cadherin (WB, IHC) 24 h	Norrin/frizzled-4
Xu et al.72	Mice/EP	↓ ZO-1/VE-cadherin (WB, IHC) 24 h	Thrombomodulin
Zhou et al.76	Rat/BI	↓ ZO-1 (WB) 24 h	Progranulin
Zhou et al.77	Rat/BI	↓ ZO-1 (WB) 24 h	Fisetin (flavonoid)
Chen et al.64	Rat/EP	↓ Claudin-5/occludin (WB) 24 h	PARP inhibition
Fujimoto et al.192	Mice/EP	↓ ZO-1 (WB) 24 h	Tenascin-C
Fang et al.65	Rat/EP	↓ Claudin-5/occludin (WB) 24 h	Ethyl pyruvate
Ying et al.68	Rat/EP	↓ Claudin-5/occludin (WB) 24 h	Valproic acid
Liu et al.74	Rat/BI	↓ Occludin/ZO-1	Matrine (alkaloid)
Pang et al.70	Mice/EP	↓ Occludin/ZO-1/claudin-5 (WB) 48 h	Apolipoprotein E
Yuan et al.73	Mice/EP	↓ Occludin/ZO-1 (WB) 24 h	Curcumin
Fan et al.61	Rat/EP	↓ Claudin-5/ZO-1 (WB) 24 h	Eph receptor-A4/Fasudil (ROCK inhibition)

^↓: decrease, ↔: no change.

EP: endovascular perforation; BI: blood injection; WB: Western blot; IHC: immunohistochemistry; HIF-1α: hypoxia inducible factor-1α; MMPs: matrix metalloproteinases; PARP: Poly (ADP-ribose) polymerase; ROCK: RhoA kinase.