Table 1.
Randomised controlled trials in progress
| Title | Country | Summary | Current status | Registration number | Links |
|---|---|---|---|---|---|
| AIRWAYS-2 randomised controlled trial of i-gel supraglottic airway device versus tracheal intubation in the initial airway management of out of hospital cardiac arrest [36] |
United Kingdom | Cluster randomised trial comparing tracheal intubation with supraglottic airway (i-gel) insertion as the initial airway in out-of-hospital cardiac arrest. Primary outcome: neurological outcome at hospital discharge or at 30 days if still hospitalised |
Enrolment completed August 2017 | ISRCTN08256118 | https://www.ncbi.nlm.nih.gov/pubmed/27697605 |
| Pragmatic Airway Resuscitation Trial (PART) [35] | United States of America | Cluster randomised trial comparing tracheal intubation and laryngeal tube insertion in out-of-hospital cardiac arrest. Primary outcome: 72-h survival |
Enrolment completed 2017 | NCT02419573 |
https://www.ncbi.nlm.nih.gov/pubmed/26851059
Initial results presented and available at https://www.eventscribe.com/2018/SAEM/agenda.asp?h=Plenary&BCFO=PL (accessed 31 May 2018) |
| Reduction of oxygen after cardiac arrest: The EXACT trial | Australia | Phase 3 Randomised controlled trial comparing oxygen titrated to saturations of 90–94% with 98–100% as soon as possible after ROSC and continued until ICU admission. Primary outcome: survival to hospital discharge. |
Enrolment starts October 2017 | NCT03138005 | https://clinicaltrials.gov/ct2/show/record/NCT03138005?term=Reduction+of+oxygen+after+cardiac+arrest&rank=1 |
| Targeted therapeutic mild hypercapnia after resuscitated cardiac arrest (TAME) | Australia | Randomised controlled trial comparing mild hypercapnia (PaCO2 50–55 mmHg) with targeted normocapnia (PaCO235–45 mmHg). Primary outcome: neurological outcome at 6 months (GOSE) |
Enrolment starts December 2017 | NCT03114033 | https://clinicaltrials.gov/ct2/show/NCT03114033 |
| Targeting low- or high-normal Carbon dioxide, Oxygen, and Mean arterial pressure After Cardiac Arrest and REsuscitation: study protocol for a randomised pilot trial [74] | Finland | Feasibility study | Enrolment complete | NCT02698917 | https://clinicaltrials.gov/ct2/show/NCT02698917 |