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. 2018 Aug 14;11:470. doi: 10.1186/s13071-018-3000-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Inhibitory effects of individual and co-treatment of Aedes aegypti cecropins on LPS-induced pro-inflammatory cytokines production in mouse peritoneal macrophages and human PBMCs. Inhibitory effects of AeaeCec1-5 on LPS-stimulated inflammatory response were analyzed by ELISA assay. Production of TNF-α, IL-1β andIL-6 in peritoneal macrophages (a-c) and in human PBMCs (d-f) were analyzed 6 h after LPS (100 ng/ml) incubation in presence of PBS, individual AeaeCec peptides (5 μM), AeaeCec1-5 mixture (1 μM each), cecropin-TY1 (CTY, 5 μM) and scrambled cecropin-TY1 (sCTY, 5 μM) as control peptide [25]. Data are presented as mean ± SEM from three independent experiments. *P < 0.05, **P < 0.01