Fig. 7.

Expected yield and on-target fold-enrichment. Dashed lines indicate the number of down-sampled reads. a and (b): Predicted median value and variance (across 100 bootstrap replicates) of the number of on-target reads, as a function of total sequenced reads. The points depict the observed numbers of on-target reads in the down-sampled libraries. c and (d): Expected enrichment of on-target reads versus number of sequenced reads for each condition and each sample