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. Author manuscript; available in PMC: 2019 Jul 6.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2018 Jul 6;137:63–68. doi: 10.1016/j.prostaglandins.2018.07.001

Figure 2.

Figure 2.

Effects of HET0016 and TRPV1 inhibition on neuronal injury. Cell viability was assessed with the CellTiter-Blue assay. (A) TRPV1 inhibitor A784168 at 10 and 50 μM protected OGD neurons at 24 h of reoxygenation. (B, C) A784168 (10 μM, B) and TRPV1 genetic knockout (KO, C) each protected neurons from OGD injury. HET0016 did not augment protection. (D) A784168 and HET0016 each attenuated H-I brain injury in newborn mice at 1 day of recovery (n=20-25/group), but did not exhibit additive effects. TRPV1 KO also protected H-I brains at 1 day. *p<0.05 vs wild-type (WT)+control procedure (Cont); #p<0.05 vs WT OGD/H-I+vehicle (Veh).