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. Author manuscript; available in PMC: 2019 Jul 6.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2018 Jul 6;137:63–68. doi: 10.1016/j.prostaglandins.2018.07.001

Figure 5.

Figure 5.

Effects of TRPV1 and NADPH oxidase 2 (NOX2) on 20-HETE-induced ROS production. (A) The NOX2 inhibitor gp91 ds-tat dose-dependently reduced 20-HETE mimetic-induced ROS production, as measured by the presence of 2',7'-dichlorodihydrofluorescein diacetate (DCFDA). Scrambled gp91 ds-tat was used as a control. (B) TRPV1 knockout (KO) and gp91 ds-tat (5 μM) each attenuated 20-HETE mimetic-induced ROS production but did not exhibit additive effects when combined. *p<0.05 vs vehicle treatment only on wild-type neurons; #p<0.05 vs 20-5,14-HEDGE treatment only on wild-type neurons.