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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: J Intern Med. 2016 Jun 16;281(1):25–40. doi: 10.1111/joim.12528

Fig. 5.

Fig. 5

C-peptide-induced cFos mRNA expression in the human retinal pigment epithelial cell line ARPE-19. ARPE-19 cells were incubated in either low (5.5 mM) or high (25 mM) glucose for 24 h prior to exposure to vehicle, 1 nM C-peptide, or 1 nM C-peptide with 1 nM insulin for 1 h. Cells were lysed, RNA isolated, and changes in cFos mRNA expression evaluated using quantitative PCR. **P < 0.01, ***P < 0.001 vs. low glucose, vehicle-treated cells; #P < 0.01 vs. low glucose, C-peptide-treated cells.