Table 6.
Effect of JPP treatment on the activity of antioxidant enzymes in the liver of control and diabetic rats.
| Control | Diabetic | ||||
|---|---|---|---|---|---|
| Vehicle | JPP-I | JPP-II | JPP-III | ||
| SOD (U/mg ptn) | 27.2 ± 0.7 | 18.7 ± 0.7∗ | 21.0 ± 1.3∗ | 19.3 ± 0.9∗ | 20.4 ± 1.7∗ |
| CAT (K/mg ptn) | 32.6 ± 1.8 | 16.8 ± 0.9∗ | 17.3 ± 0.9∗ | 19.2 ± 1.0∗ | 20.1 ± 3.3∗ |
| TrxR-1 (nmol DTNB/min/mg ptn) | 14.1 ± 0.6 | 7.3 ± 0.7∗ | 9.8 ± 0.9∗ | 8.8 ± 0.9∗ | 9.0 ± 1.1∗ |
| GPx (nmol NADPH/min/mg ptn) | 4.0 ± 0.8 | 1.7 ± 0.6∗ | 1.1 ± 0.3∗ | 1.1 ± 0.2∗ | 1.9 ± 0.4∗ |
| GR (nmol NADPH/min/mg ptn) | 13.3 ± 1.1 | 9.6 ± 2.4 | 9.9 ± 0.7 | 13.3 ± 1.6 | 3.8 ± 0.7∗# |
| GST (nmol CDNB/min/mg ptn) | 504.1 ± 13.6 | 400.3 ± 28.4∗ | 344.5 ± 16.7∗ | 377.7 ± 22.8∗ | 356.3 ± 44.3∗ |
Data are presented as means ± SEM (n=8); ∗different from the control group (CAT, SOD, and TrxR-1: Kruskal–Wallis multiple comparison test and GST, GPx, and GR: ANOVA-Duncan's test, p < 0.05); JPP: jaboticaba peel powder; SOD: superoxide dismutase; CAT: catalase; TrxR-1: thioredoxin reductase-1; GPx: glutathione peroxidase; GR: glutathione reductase; GST: glutathione S-transferase; ptn: protein; DTNB: 5,5′-ditiobis(2-nitrobenzoic acid); NADPH: nicotinamide adenine dinucleotide phosphate reduced; CDNB: 1-chloro-2,4-dinitrobenzene.