Table 2.

Effect of 2-methoxyestradiol (2ME) on prostate weight and prostate index (prostate weight/body weight ratio) in testosterone-induced BPH in rats.

	Rat weight (g)	Prostate weight (mg)	Prostate index (×103)
Control	283 ± 42.0	0.471 ± 0.048	1.54 ± 0.063
Testosterone (test)	295 ± 18.9	0.830a ± 0.058	2.97a ± 0.326
Test + 2ME 50 mg/kg	233a,b ± 13.6	0.552a,b ± 0.067	2.45a,b ± 0.271
Test + 2ME 100 mg/kg	235a,b ± 17.8	0.397a,b ± 0.051	1.57b ± 0.162

Data are expressed as mean ± SD. a or b: statistically significant from control or testosterone group, respectively, at P < 0.05 using one-way ANOVA followed by Tukey's post hoc test.