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Effect of leptin on the cardiac rate-pressure product. (a) Plot of heart rates (beats per minute, mmHg) of leptin-perfused and control hearts. (b) Plot of heart contraction pressures of leptin-perfused and control hearts. (c) Heart rate-pressure product of leptin-perfused and control hearts; ∗p < 0.05 (n = 4). The concentration of leptin was 3.1 nM in the perfusion solution.
