Table 2.
Changes in the visual analogue scale (VAS) for each question after 1 week treatment with either a gel containing hyaluronic acid, trehalose, and carbomer (HTC-gel) or eye drops containing hyaluronic acid (HT) PRN.
| Baseline | Study day | p value (time effect, ANOVA) | p value (between groups) | |
|---|---|---|---|---|
| “What is your global satisfaction concerning your eyes when awakening in the morning?” | ||||
| HT | 26.9 ± 22.5 | 25.0 ± 22.8 | 0.48 | 0.59 |
| HTC-gel | 27.1 ± 26.0 | 26.8 ± 25.1 | ||
|
| ||||
| Feeling of swollen eyelid when awakening | ||||
| HT | 23.9 ± 23.8 | 21.9 ± 24.5 | 0.68 | 0.38 |
| HTC-gel | 24.9 ± 25.5 | 25.6 ± 25.2 | ||
|
| ||||
| Subjective evaluation of ocular comfort during the night | ||||
| HT | 25.7 ± 23.1 | 26.2 ± 24.2 | 0.56 | 0.36 |
| HTC-gel | 27.0 ± 25.0 | 24.9 ± 23.3 | ||
|
| ||||
| Quality of sleep | ||||
| HT | 29.8 ± 30.6 | 23.9 ± 26.4 | 0.01 | 0.87 |
| HTC-gel | 30.7 ± 29.8 | 25.5 ± 29.1 | ||
|
| ||||
| Mean VAS score | ||||
| HT | 26.7 ± 21.3 | 23.7 ± 20.7 | 0.08 | 0.67 |
| HTC-gel | 27.5 ± 23.6 | 25.7 ± 22.5 | ||