Table 2:
Relationship of pANCA to Clinical and Laboratory Features in Children Newly Diagnosed with UC
| pANCA- | pANCA+ | P | pANCA + and < 100 | pANCA ≥ 100 | P comparing pANCA-, <100, ≥100 | |
|---|---|---|---|---|---|---|
| N = 139 | N = 260 | N = 184 | N = 76 | |||
| Age, mean (SD) | 12.5 ± 3.6 | 12.8 ± 3.1 | 0.29 | 12.7 ± 3.2 | 13.1 ± 2.8 | 0.41 |
| pANCA (%) stratified by age categories | — | — | 0.22 | — | — | 0.26 |
| 4–6 | 14/25 (56%) | 11/25 (44%) | 0.022 | 10/25 (40%) | 1/25 (4%) | 0.03b |
| 7–10 | 20/65 (31%) | 45/65 (69%) | — | 31/65 (48%) | 14/65 (22%) | — |
| 11–13 | 41/111 (37%) | 70/111 (63%) | — | 49/111 (44%) | 21/111 (19%) | — |
| 14–17 | 64/198 (32%) | 134/198 (68%) | — | 94/198 (47%) | 40/198 (20%) | — |
| Disease extent (%) | — | — | 0.60 | — | — | 0.004 |
| Proctosigmoiditis | 12 (9%) | 12 (5%) | — | 11 (6%) | 1 (1%) | — |
| Left-sided colitis | 12 (9%) | 29 (11%) | — | 27 (15%) | 2 (3%) | — |
| Extensive /Pancolitisa | 115 (83%) | 219 (84%) | — | 146 (79%) | 73 (96%) | — |
| PUCAI, mean (SD) | 48.3 ± 20.6 | 50.8 ± 19.6 | 0.23 | 50.6 ± 20.1 | 51.4 ± 18.3 | 0.45 |
| PUCAI score (%) | — | — | 0.24 | — | — | 0.47 |
| 10–30 | 41 (29%) | 54 (21%) | — | 39 (21%) | 15 (20%) | — |
| 35–60 | 53 (38%) | 119 (46%) | — | 81 (44%) | 38 (50%) | — |
| ≥65 | 45 (32%) | 87 (33%) | — | 64 (35%) | 23 (30%) | — |
| Mayo Endoscopic Sub-score (%) | — | — | 0.50 | — | — | 0.55 |
| Grade 1 | 23 (17%) | 30 (12%) | — | 21 (11%) | 9 (12%) | — |
| Grade 2 | 69 (50%) | 141 (54%) | — | 104 (57%) | 37 (49%) | — |
| Grade 3 | 47 (34%) | 89 (34%) | — | 59 (32%) | 30 (39%) | — |
| Relative rectal sparing (%) | 13/139 (9%) | 23/259 (9%) | 0.88 | 13/183 (7%) | 10/76 (13%) | 0.30 |
| Basal plasmacytosis (%) | 56/111 (50%) | 112/210 (53%) | 0.62 | 74/151 (49%) | 38/59 (64%) | 0.12 |
| Hgb (g/dL) | N = 130 | N = 246 | 0.59 | N = 176 | N = 70 | 0.53 |
| Mean (SD) | 11.5 ± 2.4 | 11.4 ± 2.1 | — | 11.5 ± 2.1 | 11.2 ± 2.1 | — |
| ESR (mm/hr) | N = 126 | N = 236 | 0.043 | N = 170 | N = 66 | — |
| Median (IQR) | 22 (11, 35) | 26 (12, 47) | — | 23 (11,41) | 34 (22,55) | <0.0001 |
| Albumin (g/dL) | N = 139 | N = 258 | 0.39 | N = 182 | N = 76 | |
| Mean (SD) | 3.7 ± 0.7 | 3.6 ± 0.7 | 3.7 ± 0.7 | 3.6 ± 0.7 | 0.43 | |
| Calprotectin (mcg/g) | N = 82 | N = 146 | 0.20 | N = 108 | N = 38 | — |
| Median (IQR) | 2023 (1083,3975) | 2676 (1378,3928) | — | 2932 (1414,4036) | 1754 (1088,3544) | 0.17 |
| CRP or hsCRP (%) | N = 103 | N = 192 | — | N = 142 | N = 50 | — |
| >ULN | 40 (39%) | 92 (48%) | 0.13 | 63 (44%) | 29 (58%) | 0.08 |
| >2xULN | 27 (26%) | 64 (33%) | 0.21 | 45 (32%) | 19 (38%) | 0.32 |
| CBir1 positive (%) | 33 (24%) | 44 (17%) | 0.10 | 28 (15%) | 16 (21%) | 0.14 |
aExtensive/Pancolitis /Unassessable due to severity of disease were all included in this group. b Comparison of pANCA for age <7 vs age ≥7.