Table 3:
Relationship of CBir1 to clinical and laboratory features of children newly diagnosed with UC
| CBir1+ N = 77 | CBir1- N = 322 | P | |
|---|---|---|---|
| Age, mean (SD) | 10.9 ± 3.6 | 13.1 ± 3.1 | <0.0001 |
| CBIR (%) stratified by age categories | <0.0001 | ||
| 4–6 | 11/25 (44%) | 14/25 (56%) | — |
| 7–10 | 21/65 (32%) | 44/65 (68%) | — |
| 11–13 | 25/111 (23%) | 86/111 (77%) | — |
| 14–17 | 20/198 (10%) | 178/198 (90%) | — |
| Disease extent (%) | 0.041 | ||
| Proctosigmoiditis | 0 (0%) | 24 (7%) | — |
| Left-sided colitis | 7 (9%) | 34 (11%) | — |
| Extensive /Pancolitisa | 70 (91%) | 264 (82%) | — |
| PUCAI, mean (SD) | 45.7 ± 21.4 | 51.0 ± 19.4 | 0.052 |
| PUCAI score (%) | 0.095 | ||
| 10–30 | 25 (32%) | 70 (22%) | — |
| 35–60 | 30 (39%) | 142 (44%) | — |
| ≥65 | 22 (29%) | 110 (34%) | — |
| Mayo Endoscopic Sub-score (%) | |||
| Grade 1 | 13 (17%) | 40 (12%) | 0.18 |
| Grade 2 | 42 (55%) | 168 (52%) | — |
| Grade 3 | 22 (29%) | 114 (35%) | — |
| Relative rectal sparing (%) | 12/76 (16%) | 24/322 (7%) | 0.023 |
| Basal plasmacytosis (%) | 22/58 (38%) | 146/263 (56%) | 0.015 |
| Hgb (g/dL) | 11.0 ± 2.2 | 11.5 ± 2.2 | 0.063 |
| Mean (SD) | N = 75 | N = 301 | — |
| ESR (mm/hr) | 25 (16, 49) | 24 (12, 40) | 0.33 |
| Median (IQR) | N = 70 | N = 292 | — |
| Albumin (g/dL) | 3.7 ± 0.8 | 3.6 ± 0.7 | 0.26 |
| Mean (SD) | N = 77 | N = 320 | |
| Calprotectin (mcg/g) | 1495 (971, 3333) | 2634 (1324, 4022) | 0.046 |
| Median (IQR) | N = 35 | N = 193 | — |
| CRP or hsCRP (%) | |||
| >ULN | 24 (44%) | 108 (45%) | 0.85 |
| >2xULN | 17 (31%) | 74 (31%) | 0.99 |
| N = 55 | N = 240 | — | |
| 25-OH Vitamin D (ng/mL) | 30.9 (27.2,38.0) | 27.6 (23.0,33.4) | 0.0002 |
| Median (IQR) | N = 75 | N = 317 | — |
| 25-OH Vitamin D (%) | — | — | 0.0009 |
| <20 Deficient | 5 (7%) | 37 (12%) | — |
| 20-< 30 Insufficient | 25 (33%) | 159 (50%) | — |
| ≥30 Sufficient | 45 (60%) | 121 (38%) | 0.005b |
| pANCA positive (%) | 44 (57%) | 216 (67%) | 0.10 |
aExtensive/Pancolitis /Unassessable due to severity of disease were all included in this group.
b P value for association of CBir1 with 25-OH vitamin D ≥30 stratified by age-group based on a Mantel-Haenszel χ2 test.