Figure 5.

A selection of pharmaceutical compounds that target major players or key nodes in metabolic circuits, such as AMPK and sirtuins. Via altered transcription factors, these compounds act on mitochondrial function and positively affect metabolic flexibility. See “Pharmaceuticals” for a brief description of the examples mentioned here. Ac, acetyl; NA, nicotinic acid; NMN, nicotinamide mononucleotide; NR, nicotinamide riboside; P, phosphate; PARPi, poly (ADP-ribose) polymerase inhibitor; TF, transcription factor.