Table 2.
Brain areas showing a significantly greater brain response for face-name pairs in older adults with MCI compared to healthy controls (BA = Brodmann's Area; R = right; L = left; C = cluster ≥ 896 mm3; PSC = Percent Signal Change)
| Anatomical location | BA/subregion | Volume (mm3) | Center (x,y,z) | T-value at peak intensity | PSC MCI | PSC CH | Cohen's d | ||
|---|---|---|---|---|---|---|---|---|---|
| Novel vs. Repeated Twice Contrast | |||||||||
| C1 | Focus Point | Right Cerebellar Tonsil | 6976 | R26, A37, I32 | 2.66 | −0.56 | 0.12 | 0.78 | |
| Cerebellum | Right Culmen | ||||||||
| Right Cerebellum (IX) | |||||||||
| Subcortical | Right Parahippocampal Gyrus | R BA 27, 30, 35 | |||||||
| Right Thalamus | |||||||||
| Right Pulvinar | |||||||||
| Temporal | Right Fusiform Gyrus | ||||||||
| Occipital | Right Lingual Gyrus | R BA 18, 19 | |||||||
| C2 | Focus Point | Cingulate | 2112 | R2, P1, S20 | 2.78 | −0.80 | −0.06 | 0.81 | |
| Basal Ganglia | Caudate | ||||||||
| Right Caudate Body | |||||||||
| Subcortical | Thalamus | ||||||||
| Corpus Callosum | |||||||||
| C3 | Focus Point | Left Parahippocampal Gyrus | L BA 30 | 1536 | L14, P37, I4 | 2.79 | −0.59 | 0.14 | 0.81 |
| Cerebellum | Left Culmen | ||||||||
| Subcortical | Left Thalamus | ||||||||
| C4 | Focus Point | Left Lentiform Nucleus | 1344 | L22, P1, S4 | 2.60 | −0.42 | 0.20 | 0.76 | |
| Basal Ganglia | Left Putamen | ||||||||
| Subcortical | Left Parahippocampal Gyrus | ||||||||
| Cerebellum | Left Culmen | ||||||||
| C5 | Focus Point | Thalamus | 1344 | L2, P17, S4 | 2.55 | −0.53 | 0.15 | 0.74 | |
| Left Red Nucleus | |||||||||
| Posterior Commissure | |||||||||
| Subcortical | Left Medial Dorsal Nucleus | ||||||||
| Left Mammilary Body | |||||||||
| Left Ventral Posterior Lateral Nucleus | |||||||||
| C6 | Focus Point | Cingulate Gyrus | 896 | R2, P13, S24 | 2.66 | −0.82 | 0.19 | 0.78 | |
| Repeated Once vs. Twice Contrast | |||||||||
| C1 | Focus Point | Right Caudate | 1728 | R10, P1, S20 | 2.64 | −0.55 | 0.29 | 0.77 | |
| Subcortical | Right Cingulate Gyrus | ||||||||
| Basal Ganglia | Right Caudate Body | ||||||||
| C2 | Focus Point | Corpus Callosum | 896 | L2, P1, S16 | 2.68 | −0.79 | 0.28 | 0.78 | |
| Subcortical | Cingulate Gyrus | ||||||||
| Left Thalamus | |||||||||
| Basal Ganglia | Left Caudate | ||||||||
Clusters shown survived our cluster threshold alpha-protection procedure (clusters: individual voxel p < 0.02, volume 896 mm3, whole brain p < .05; see text for details).