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. 2018 Jul 10;24(5):556–576. doi: 10.1093/humupd/dmy021

Figure 2.

Figure 2

Canonical epigenetic patterns. H3K4me3 is associated with actively transcribed promoters, as well as CpG islands, irrespective of transcription. H3K27ac demarks active promoters and enhancers, while associated transcribed genes bodies are enriched for H3K36me3. Repressed regions of the genome are typically associated with either H3K9me2/3 or H3K27me3. DNA is generally highly methylated throughout the genome, with the exception of regulatory regions marked by H3K4me3 and/or H3K27ac, and H3K27me3- domains. Methylated CpGs are depicted as closed circles and unmethylated CpGs are open circles.