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. 2018 Feb 8;110(8):895–904. doi: 10.1093/jnci/djx281

Figure 3.

Figure 3.

Visualization of regulatory annotations for the expanded chromosome 4q32.1 genetic signal associated with premature menopause in neuron and ovary cell types, along with haplotype single nucleotide polymorphisms and bound transcription factors' genomic locations. A) Chromatin state annotations (ChromHMM) in H9- derived neuron cells. Colored genomic regions reflect chromHMM annotations for chromain states (enhancer, transcribed, Polycomb-repressed, and promoter) (23). B) ChromHMM annotations in ovary cells. C) ENCODE histone modifications associated with Polycomb-repressed regions (H3K27me3) for H9-derived neurons (23). D) H3K27me3 marks for placenta amnion cells (ovary cell data unavailable) (23). E) ENCODE histone modifications associated with repressed regions (H3K9me3) for H9-derived neurons (23). F) H3K9me3 marks for ovary cells (23).