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. 2017 Nov 21;24(1):2–13. doi: 10.1093/molehr/gax061

Figure 4.

Figure 4

The effect of CYP27A1 knockdown on P4 secretion and aminoglutethimide-induced changes in LXR and SREBP2 target gene mRNA expression in human luteinized granulosa cells. Panel (A) displays QPCR data for CYP27A1 and panel (B) is P4 secretion in the presence and absence of hCG. Panels (C and D) are ABCA1 and LDLR mRNA expression in response to aminoglutethimide, respectively. For all charts, data are displayed as the fold change relative to DMSO-treated, control siRNA-transfected cells. Error bars indicate one SEM. Brackets indicate significant differences between the indicated groups due to CYP27A1 siRNA transfection, and asterisks denote significant differences due to hCG (Panel B) or aminoglutethimide (Panels C, D) within the respective siRNA transfection group; *P < 0.05, ***P < 0.001.