Table 2.

Significant SNP and associated genes for 10RIBBFT in the combined analysis and meta-analysis

SNP name	SSC	Location, bp	P (combined)-value1	P (meta-analysis)-value2	Associated gene3	Distance,4 bp	Gene function	Effect6(%)
MARC0023432	1	63,194,355	1.29 × 10−3	1.09 × 10−8	CNR1	−8478	Signal transduction	0.042788
ASGA0004384	1	134,037,038	2.89 × 10−5	8.30 × 10−6	TNFAIP8L3	−82,677	Phospholipid transport; regulation of lipid metabolic process	0.63985
MARC0101639	4	129,079,594	7.81 × 10−6	5.23 × 10 −7	VCAM1	+25,002	Cell-matrix adhesion	0.060221
WU_10.2_6_138496555	6	138,496,555	2.45 × 10−6	1.87 × 10−8	ANGPTL3	+385,265	Glycerol, fatty acid, and phospholipid metabolic process	0.537356
H3GA0019109	6	143,021,550	7.37 × 10−6	4.99 × 10 −7	DAB1	Introns	Neuron migration	0.151069
WU_10.2_9_29774722	9	29,774,722	8.73 × 10−6	1.12 × 10 −9	EEF1A2	+132,165	Positive regulation of lipid kinase activity	0.386885
WU_10.2_11_22253325	11	22,253,325	1.74 × 10−5	2.19 × 10−3	ENSSSCG000000 23738	Introns	Intracellular protein transport	0.043826
MARC0109867	15	38,679,115	1.79 × 10−4	1.06 × 10 −9	ENSSSCG000000 29846	+407,341	Striated muscle contraction	0.047907
ASGA0091668	15	41,967,209	3.46 × 10 −6	3.19 × 10−4	ENSSSCG000000 23144	+354,274	NA5	0.170797
WU_10.2_16_22135509	16	22,135,509	9.11 × 10−6	2.94 × 10−5	SPEF2	Introns	NA	0.30447
WU_10.2_17_64641249	17	64,641,249	3.41 × 10 −6	5.41 × 10−6	BMP7	−103,697	Organ morphogenesis and development	0.099771
WU_10.2_17_65044153	17	65,044,153	1.26 × 10−5	8.15 × 10 −8	PCK1	−50,630	Gluconeogenesis; lipid and glucose metabolic process	0.059291
ALGA0096314	17	65,125,689	2.21 × 10−7	1.37 × 10 −9	PCK1	+24,938	Gluconeogenesis; lipid and glucose metabolic process	0.320835

¹ P _(combined)-value = P-value from the combined analysis. The bold data in this column represent the significant SNP at genome-wide significant level; otherwise at the chromosome-wide significant level.

² P _{(meta-analysis)}-value = P-value from the meta-analysis. The bold data in this column represent the significant SNP at genome-wide significant level.

³ PCK1 = phosphoenolpyruvate carboxykinase 1; ANGPTL3 = angiopoietin-like 3; BMP7 = bone morphogenetic protein 7; DAB1 = disabled homolog 1; VCAM1 = vascular cell adhesion molecule 1; EEF1A2 = eukaryotic translation elongation factor 1 alpha 2; SPEF2 = sperm flagellar 2; TNFAIP8L3 = TNF alpha induced protein 8-like 3; CNR1 = cannabinoid receptor 1. The associated genes in bold in this column represent these genes were associated with traits based on annotation.

⁴+/− = the location of SNP in downstream/upstream of the nearest gene.

⁵NA = not available.

⁶Effect = the proportion of additive genetic variance explained by the identified SNP.