FIG. 3.

Effect of dofetilide, quinidine, moxifloxacin, ranolazine and verapamil on iPSC-CM APDc, FPDc and clinical QTc. For each drug, left panels show relative drug-induced channel block from patch clamp experiments, the error bars represent ±SE of mean percent channel block. The vertical lines represent clinical Cmax (solid line) and drug doses in iPSC-CMs experiments (dashed lines). The middle and right panels show drug-induced changes in APDc and FPDc in iCell and Cor.4U, and clinical QTc. 95% confidence intervals are shown as error bars in ΔΔAPDc and ΔΔFPDc and in gray shading for the clinical QTc data. The tables represent the number of wells in acute iPSC-CM experiments where drug-induced arrhythmic events or cessation of spontaneous contractions (Q) were observed in MEA and VSD, along with the type (A, B, C, or T) of the arrhythmia (for VSD).