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. 2018 Aug 15;4(8):eaar6637. doi: 10.1126/sciadv.aar6637

Fig. 3. Genetic or pharmacological rescue of motor coordination deficits, psychostimulant hypersensitivity, and sensorimotor gating deficits in Df1/+ mice.

Fig. 3

(A) Latency to fall (in seconds) from the rotarod was scored three times per day over three consecutive days. WT control (n = 8), Df1/+ (n = 8), Df1/+;Snca/+ (n = 8), and Snca/+ (n = 8) mice were tested at 3.5 months of age. Statistical significance (two-way ANOVA with repeated measures: F3,28 = 9.552, P = 0.0250); *P < 0.05 (Df1/+, as compared to WT) and #P < 0.05 (Df1/+, as compared to Df1/+;Snca/+) (Bonferroni post hoc test). (B) Latency to fall (seconds) from the rotarod was scored three times per day over three consecutive days. WT mice treated with vehicle (n = 10), Df1/+ mice treated with vehicle (n = 12), and Df1/+ mice treated with CCI-779 (n = 8) were tested at 3.5 months of age. Statistical significance (two-way ANOVA with repeated measures: F2,27 = 4.34, P = 0.0232); *P < 0.05 (Df1/+ mice treated with vehicle, as compared to WT) and #P < 0.05 (Df1/+ mice treated with CCI-779, as compared to Df1/+ mice treated with vehicle) (Bonferroni post hoc test). (C) Locomotor activities [distance traveled (in centimeters)] measured in the open-field box before and after MK-801 challenge were plotted in 15-min bins. WT mice treated with vehicle (n = 10), WT mice treated with CCI-779 (n = 10), Df1/+ mice treated with vehicle (n = 10), and Df1/+ mice treated with CCI-779 (n = 10) were tested at 2 months of age. Statistical significance (two-way ANOVA with repeated measures: F3,36 = 3.132, P = 0.0374); *P < 0.05 and **P < 0.01 (Bonferroni post hoc test). (D) Acoustic startle response (left) and PPI (%) of startle response (right) were evaluated. WT mice treated with vehicle (n = 10), WT mice treated with CCI-779 (n = 10), Df1/+ mice treated with vehicle (n = 10), and Df1/+ mice treated with CCI-779 (n = 10) were tested at 2 months of age. Statistical significance (two-way ANOVA with repeated measures: F3,36 = 4.347, P = 0.0103); *P < 0.05 and **P < 0.01 (Bonferroni post hoc test).